PT-141 (Bremelanotide)

FDA-approved for female sexual arousal disorder

4.5
2 reseñas

Rating Breakdown

Libido Enhancement
4.5
Sexual Function
4.5
Regulatory Approval Status
5.0
Onset Speed
3.5
CNS-Mediated (Non-Vascular)
5.0
Safety & Side Effects
3.5

Resumen

PT-141 (Bremelanotide) is a melanocortin receptor agonist approved by the FDA for treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women.

Key Information

Identity
Also Known As Bremelanotide; Vyleesi
Sequence Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
CAS Number 189691-06-3
Molecular Formula C50H68N14O10
Properties
Half-Life 2-3 hours
Administration subcutaneous injection
Dosage Range 1.75 mg as needed
Price Range $2.0–$20.0/mg
Handling & Storage
Storage Refrigerated 2-8C
Reconstitution Pre-filled auto-injector
Regulatory Status
US Status FDA-approved (Vyleesi)
Legal Status FDA-approved as Vyleesi for female HSDD.
Research Papers 1 indexed

Mecanismo

Activates melanocortin receptors in the brain, specifically MC4R, to increase sexual desire independently of the vascular system.

Benefits

  • Increased sexual desire
  • FDA-approved for HSDD
  • Brain-mediated (not vascular)
  • On-demand use

Side Effects

  • Nausea (40%)
  • Flushing
  • Headache
  • Skin darkening

Contraindications

  • Cardiovascular disease
  • Pregnancy

Evidence Summary

FDA-approved based on Phase 3 trials for hypoactive sexual desire disorder.

Research

FDA-approved as Vyleesi based on Phase 3 trials showing significant improvement in sexual desire and distress.

Ver Investigación

Safety

FDA-approved. Side effects: nausea, flushing, headache.

Legal Status

FDA-approved as Vyleesi for female HSDD.

Investigación

1 artículos de investigación indexados

Ver Investigación

Write a Review

Rating Breakdown

Eficacia
4.5
Seguridad
3.5
Valor
4.0
Overall
4.5

Based on 2 reseñas.

Reseñas

FDA-approved and it works 2026-06-22
Hannah H.

PT-141 (bremelanotide) restored my libido completely. The fact it's FDA-approved for HSDD is a major plus. Brain-mediated mechanism is different from vascular drugs - works on desire not just blood flow. On-demand use is convenient.

Eficacia: 5/5 Seguridad: 4/5 Valor: 4/5
Works differently than expected 2026-06-12
Tom V.

PT-141 takes about 2 hours to kick in. The desire increase is real - not just physical. Nausea is the main side effect. FDA approval makes me feel safe. Better than PDE5 inhibitors for psychological ED.

Eficacia: 4/5 Seguridad: 3/5 Valor: 4/5