The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice

AOD9604 (GH lipolytic fragment) reduced body weight and body fat in obese mice after 14 days, increasing beta(3)-adrenergic receptor expression in fat cells.

Abstract

Both human GH (hGH) and a lipolytic fragment (AOD9604) synthesized from its C-terminus are capable of inducing weight loss and increasing lipolytic sensitivity following long-term treatment in mice.. One mechanism by which this may occur is through an interaction with the beta-adrenergic pathway, particularly with the beta(3)-adrenergic receptors (beta(3)-AR).. Here we describe how hGH and.

Key Findings

Both human GH (hGH) and a lipolytic fragment (AOD9604) synthesized from its C-terminus are capable of inducing weight loss and increasing lipolytic sensitivity following long-term treatment in mice. | Here we describe how hGH and AOD9604 can reduce body weight and body fat in obese mice following 14 d of chronic ip administration. | These results correlate with increases in the level of expression of beta(3)-AR RNA, the major lipolytic receptor found in fat cells.

Study Design

Animal study