Retatrutide

Triple agonist (GLP-1/GIP/Glucagon) — next-gen weight loss

4.7
3 리뷰

Rating Breakdown

Weight Loss Efficacy
5.0
Appetite Suppression
4.7
Metabolic Improvement
4.7
Body Composition
4.3
Glycemic Control
4.3
Safety & Side Effects
3.0
Cardiovascular Benefit
2.7
Dosing Convenience
3.0

개요

Retatrutide is a triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors. It represents the next generation of obesity pharmacotherapy.

Key Information

Identity
Also Known As LY3437943
Sequence Triple agonist peptide
CAS Number 2378660-54-7
Molecular Formula C221H342N46O48
Properties
Half-Life 6 days
Administration subcutaneous injection
Dosage Range 1-12 mg weekly
Price Range $4.0–$35.0/mg
Handling & Storage
Storage Refrigerated 2-8C
Reconstitution Reconstitute with bacteriostatic water
Regulatory Status
US Status Investigational (Phase 3)
Legal Status Investigational — not yet FDA-approved. In Phase 3 TRIUMPH trials.
Research Papers 1 indexed

Mechanism

Triple agonism of GLP-1 (appetite suppression), GIP (insulin sensitization), and glucagon (fat oxidation and thermogenesis) receptors.

Benefits

  • Up to 24.2% weight loss
  • Triple hormone agonist
  • Highest efficacy in trials

Side Effects

  • Nausea
  • Diarrhea
  • Vomiting

Contraindications

  • Not studied in pregnancy

Evidence Summary

Phase 2 showed 24.2% weight loss at 48 weeks. Phase 3 TRIUMPH trials ongoing.

Research

Phase 2 trials showed up to 24.2% weight loss at 48 weeks, the highest of any peptide in clinical trials.

View Research

Safety

Similar GI side effects to GLP-1 class. Still in Phase 3 development.

Legal Status

Investigational — not yet FDA-approved. In Phase 3 TRIUMPH trials.

연구

1 research papers indexed

View Research

Write a Review

Rating Breakdown

Effectiveness
5.0
Safety
3.0
Value
4.0
Overall
4.7

Based on 3 리뷰.

리뷰

33 lbs in 3 months on 6mg 2026-07-15
Robert Z.

Started taking Reta in May 2026 and 3 months later I'm down 33 lbs. Taking 6mg but weight loss has gotten slower. Thinking about going up to 8mg. The triple agonist mechanism is unreal.

Effectiveness: 5/5 Safety: 3/5 Value: 4/5
Reversed my type 2 diabetes 2026-07-04
Robert Z.

Reta reversed my type 2 diabetes. A1C normalized within 4 months. Also lost 25 lbs. The heart rate increase is real though - monitoring that closely with my doctor.

Effectiveness: 5/5 Safety: 3/5 Value: 4/5
Incredible results but watch the sides 2026-04-30
Robert Z.

Down 28 lbs in 4 months. The weight loss is unmatched but increased heart rate is a real side effect. Also noticed it blunted my dopamine - lost interest in unhealthy habits which was actually positive.

Effectiveness: 5/5 Safety: 3/5 Value: 4/5