Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults
Authors: Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, et al.
Journal
J Clin Endocrinol Metab
Year
2006
Citations
400
Type
Clinical Trial
Subject
Human
Condition
Growth Hormone Deficiency
TL;DR
CJC-1295, a long-acting GHRH analog, prolonged GH and IGF-1 secretion in healthy adults across two randomized placebo-controlled dose-escalation trials (28 and 49 days).
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DOI: 10.1210/jc.2005-1536
Abstract
Therapeutic use of GHRH to enhance GH secretion is limited by its short duration of action.. The objective of this study was to examine the pharmacokinetic profile, pharmacodynamic effects, and safety of CJC-1295, a long-acting GHRH analog.. The study design was two randomized, placebo-controlled, double-blind, ascending dose trials with durations of 28 and 49 d.